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揭示了甲基物质和多甲基物质与前列腺增生之间的复杂联系

Tian Wang¹, Jijingru Yang², Yapeng Han³

¹Research Center for Translational Medicine, the Second Affiliated Hospital of Anhui Medical University; School of Public Health, Anhui Medical University, Hefei 230601, China; Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China.

The Science of the total environment

|May 10, 2024

概括

perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 与前列腺增生有关. 较高的PFAS暴露表明与前列腺特异性抗原 (PSA) 度量具有剂量依赖的关联,表明潜在的危害.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 在环境和消费品中被广泛检测到.
人们越来越担心PFAS对健康的潜在影响,特别是对前列腺健康的影响.

研究的目的:

调查暴露于特定PFAS (PFDeA,PFOA,PFOS,PFHxS,PFNA) 和前列腺健康之间的关联.
使用机器学习评估PFAS暴露与前列腺特异抗原 (PSA) 度量之间的关系.

主要方法:

对五种特定的PFAS化合物的血清水平的分析.
应用机器学习算法来评估PFAS和f/tPSA比率之间的剂量反应关系.
统计分析以确定PFAS混合物与前列腺增生之间的关联.

主要成果:

在PFOS和f/tPSA比率之间发现了线性,积极的剂量依赖关系.
观察到PFDeA,PFOA,PFHxS和PFNA与f/tPSA比率的非线性剂量反应关系.
确定了PFAS混合物和前列腺增生之间的积极关联,PFNA和PFOS显示出最显著的影响.

结论:

PFDeA,PFOA,PFOS和PFNA的血清水平升高与前列腺增生的风险增加有关.
机器学习技术有效地确定了PFAS对前列腺健康的潜在危险影响.
这些发现突出了对PFAS毒理学和公共卫生影响的进一步研究的需要.

关键词:

环境毒性环境毒性尼汉斯 (NHANES) 是一个名人.-和多基基物质 (PFAS) 的使用.前列腺增生症前列腺增生症.前列腺特异性抗原 (PSA) 是什么?

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