里桑基苏马布在克罗恩病的长期结果:一个现实世界的GETAID研究
Mathurin Fumery1, Benedicte Caron2, Xavier Hébuterne3
1Department of Gastroenterology, Amiens University hospital, and PeriTox, Université de Picardie, France.
概括
这项研究表明,在一年后,在一半的克罗恩氏病患者中,瑞桑基祖马布维持治疗实现了无类固醇的临床缓解,其安全性与这种耐药人群的现有文献相一致.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 克罗恩氏病 (CD) 是一种慢性炎症性肠病,需要长期管理.
- 瑞桑基祖马布是一种用于治疗中度至重度CD的白素-23抑制剂.
- 关于CD中长期risankizumab有效性和安全性的现实数据有限.
研究的目的:
- 评估瑞桑基祖马布维持治疗的长期有效性和安全性.
- 评估一大批耐火克罗恩病患者的现实世界队列的结果.
主要方法:
- 从2021年5月到2023年8月,连续174名克罗恩氏病患者在25个中心接受瑞桑基祖马布治疗的回顾性分析.
- 主要终点:在52周内没有使用类固醇的临床缓解 (哈维·布拉德肖指数<5).
- 纳入标准:接受瑞桑基祖马布治疗的CD患者,收集了关于先前治疗和结果的数据.
主要成果:
- 在52周,46%的患者实现了无类固醇临床缓解.
- 在52周时,risankizumab的持续率为79%.
- 在29%的患者中发生了不良事件,15%的患者出现了严重不良事件.
结论:
- 瑞桑基祖马布在现实世界的一组耐火克罗恩病患者中,在实现无类固醇缓解方面表现出持续的有效性.
- 在这个队列中,risankizumab的安全性概况与之前报告的数据一致.
- 这项研究提供了有价值的见解,在临床试验之外的长期管理克罗恩氏病与risankizumab.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
131
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
131
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
158
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
158
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
115
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
115
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
125
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
125
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Inflammatory Bowel Disease II: Crohn's Disease
219
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
219


