在三个基于人口的出生队列中,母乳养时间与后代炎症性肠病风险无关
Manasi Agrawal1, Ketil Størdal2, Anne Vinkel Hansen3
1Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark; The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.
概括
无论是纯母乳养还是完全母乳养,母乳养的持续时间与后代患炎症性肠病 (IBD) 的风险无关. 这项大规模研究分析了来自三个出生队伍的数据,发现母乳养对IBD发展没有保护作用.
科学领域:
- 儿科健康 儿科健康
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 哺乳被认为对婴儿的健康和发育至关重要.
- 观察性研究表明,母乳养与炎症性肠病 (IBD) 之间存在潜在的保护性联系.
- 哺乳时间与后代IBD风险之间的确切关系尚不清楚.
研究的目的:
- 研究母乳养时间与后代患IBD的风险之间的关联.
- 分析纯母乳养时间对IBD风险的影响.
- 为了确定任何母乳养时间与IBD风险之间的关联.
主要方法:
- 利用了从三个大型基于人口的出生队伍中前性收集的数据.
- 将队列数据与国家登记处联系起来,以获得全面的后代健康信息.
- 员工调整的考克斯比例回归分析和元分析,以评估母乳养时间和IBD风险.
主要成果:
- 分析包括超过148,000 (独家) 和169,000 (任何) 后代,平均随访时间为16.3-22.3年.
- 在调整了多个共同变量后,没有发现纯母乳养时间与后代IBD风险之间的关联.
- 综合分析显示,纯母乳养或任何母乳养时间与IBD (包括克罗恩病和性结肠炎) 之间没有显著的关联.
结论:
- 纯母乳养或任何母乳养的持续时间与后代炎症性肠病的风险增加或降低无关.
- 来自三大出生队伍的研究结果表明,母乳养的持续时间不会影响晚年患IBD的可能性.
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