利用阴离子共聚合物和AgBr纳米颗粒的优势,优化基托的抗菌活性
Bin Wang1, Lei He1, Fujun Zhou1
1College of Chemistry & Chemical Engineering, Mianyang Normal University, MianYang 621000, China.
International journal of biological macromolecules
|May 10, 2024
概括
这项研究开发了一种基于酸盐的新型复合物 (AgBr@PBGDBr-C),具有双重化学和光动力学抗菌模式. 复合物对常见的细菌具有显著的有效性,对细胞的毒性低.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 抗菌研究 抗菌研究
背景情况:
- 基于酸盐 (CS) 的复合材料越来越多地被研究用于抗菌应用.
- 开发有效和安全的抗微生物药物战略对于公共卫生至关重要.
研究的目的:
- 合成一种具有增强抗菌性能的新型天然/合成复合物 (AgBr@PBGDBr-C).
- 为了研究化学接触和光动力学模式的协同抗菌作用.
- 评估开发的复合材料的生物相容性.
主要方法:
- 与环氧和四级氨基基团一起合成一种两性共聚合物 (PBGDBr).
- 与酸盐 (CS) 交叉连接PBGDBr,形成PBGDBr-C.
- 用银化物纳米颗粒 (AgBr NP) 装饰PBGDBr-C,以创建AgBr@PBGDBr-C.
- 对抗大肠杆菌和金黄色葡萄球菌的抗菌活性的评估.
- 使用L929细胞活力试验评估细胞毒性.
主要成果:
- AgBr@PBGDBr-C复合物在分别在64和128微克/毫升的度下对大肠杆菌和黄金葡萄球菌表现出显著的杀菌作用.
- 在128微克/毫升的复合物治疗的L929细胞中保持了高细胞活力 (>80%),表明细胞毒性较低.
- 复合材料采用多模式系统,结合了化学和光动力学抗菌作用.
结论:
- 开发的AgBr@PBGDBr-C复合物提供了一个有前途的多模式抗菌策略.
- 这种方法结合了化学和光动力学抗菌机制,以提高疗效.
- 该复合物具有低毒性,并有可能延迟细菌耐药性的发展.
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