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用绿色工艺制备的黄素无形纳米复合物的增强生物可用性,使用改性粉制备

Changying Chen¹, Zhixing Wang², Hongliang Fu²

¹Center for Drug Delivery System Research, School of Medicine, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China; School of Chemistry and Chemical Engineering, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China.

International journal of biological macromolecules

|May 10, 2024

概括

经过Octenyl succinic anhydride修饰的粉 (OSA-S) 用于制造黄素无形复合纳米颗粒 (Cur/OSA-S NPs). 这些纳米颗粒显著增强了黄素的功效.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

黄素 (Cur) 具有显著的药理活性,但其生物可用性较低.
较差的水溶性,化学不稳定性和低透性限制了黄素的临床应用.

研究的目的:

为了制造黄素无形复合纳米颗粒 (Cur/OSA-S NPs),使用八酸酸无水化物修饰粉 (OSA-S).
通过提高黄素的可溶性,稳定性和透性来提高黄素的生物可用性.

主要方法:

使用无溶剂的pH驱动方法来制备Cur/OSA-S NPs.
纳米粒子的表征包括尺寸,封装效率和药物负载.
无形状态通过X射线衍射 (XRD) 和微分扫描热度计 (DSC) 证实.
进行了体外溶解和并行人工膜透性测定 (PAMPA).

主要成果:

目前/OSA-S NP (大约) (大约) 128.9 nm) 实现了高封装 (90.0%) 和药物负载 (51.0%).
黄素成功地在纳米颗粒中分散到无形状态.
库尔/OSA-S NPs表现出 92 倍的可溶性,增强的稳定性 (储存,热,光) 和重新分散性.
证实了增强的溶解速率和体外透性.
与原始黄素相比,Cur/OSA-S NPs显示出更强大的癌细胞增殖抑制.

结论:

经过酸酸无水化改性粉是有效的创造黄素无形复合纳米颗粒.
开发的Cur/OSA-S NP表现出更好的溶解性,稳定性和透性.
这些发现支持基于黄素的产品在疾病治疗中的潜在发展.

关键词:

库尔库明是一种黄素.在纳米复合材料.八烯酸酸无水化粉稳定的稳定性稳定的稳定性受到pH驱动的pH驱动

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