使用基于蛋白质和的疗法来管理和预防致病病毒
Esmail M El-Fakharany1, Hamada El-Gendi2, Ahmed K Saleh3
1Protein Research Department, Genetic Engineering and Biotechnology Research Institute GEBRI, City of Scientific Research and Technological Applications (SRTA city), New Borg El-Arab, Alexandria 21934, Egypt; Pharmaceutical and Fermentation Industries Development Centre (PFIDC), City of Scientific Research and Technological Applications (SRTA-City), New Borg Al-Arab, Alexandria, Egypt.
International journal of biological macromolecules
|May 10, 2024
概括
治疗性蛋白质是重要的药物,预计到2030年将达到6530亿美元. 蛋白质工程策略提高了它们治疗疾病的有效性和稳定性.
科学领域:
- 生物技术和制药科学 生物技术和制药科学
- 重组蛋白质的生产和应用.
- 用于治疗开发的蛋白质工程.
背景情况:
- 治疗性蛋白质占制药的重要部分,其市场价值在2023年为38703亿美元,预计到2030年将达到65335亿美元.
- 关键的治疗蛋白质包括生长激素,胰岛素和干扰素 (IFN α, γ, β),对于治疗代谢障碍,瘤和病毒感染至关重要.
- 重组DNA技术使得使用各种表达系统 (核细胞和真核细胞) 大规模生产治疗性蛋白质成为可能.
研究的目的:
- 提供对治疗性蛋白质研究和开发的全面概述.
- 突出基于蛋白质的疗法的市场增长和临床意义.
- 讨论治疗蛋白质优化的挑战和先进的蛋白质工程策略.
主要方法:
- 对治疗性蛋白质生产和应用的现有文献的审查.
- 对治疗性蛋白质市场趋势和经济预测的分析.
- 探索蛋白质工程技术 (PEGylation,Fc融合等) 的研究. 克服生产和应用的局限性.
主要成果:
- 治疗性蛋白质是制药行业快速增长的部门.
- 蛋白质生产的局限性包括免疫性,稳定性和降解.
- 蛋白质工程显著改善了准,纯度,产量,功能和循环半衰期.
结论:
- 先进的蛋白质工程对于克服治疗性蛋白质开发当前的局限性至关重要.
- 对治疗性蛋白质的持续研究和洞察力将推动其成功的临床实施.
- 基于蛋白质的疗法为广泛的疾病提供了有前途的解决方案.
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