基于Populus nigra L.花提取物的一种配方的伤口愈合潜力具有抗炎活性
Amina Atia1, Dina Atmani-Kilani1, Djebbar Atmani1
1Université de Bejaia, Faculté des Sciences de la Nature et de la Vie, Laboratoire de Biochimie Appliquée, 06000, Bejaia, Algeria.
Journal of ethnopharmacology
|May 10, 2024
概括
黑 (Populus nigra) 药膏通过促进组织再生和减少炎症,显著增强了老鼠的伤口愈合. 10%的度被证明是最佳的,为伤口护理提供了有效的自然疗法.
科学领域:
- 药理学和传统医学的医学.
- 伤口治愈研究研究 伤口治愈研究
- 自然产品化学 自然产品化学
背景情况:
- 伤口愈合是一个复杂的生物过程,需要协调的细胞活动来修复组织.
- 黑人L. (黑人) 的花具有治疗伤口和炎症状况的传统医疗用途.
研究的目的:
- 为了评估黑 (Populus nigra) 药膏在老鼠切除模型中的伤口愈合效果.
- 为了确定Populus nigra乙醇提取物在治疗伤口的药膏中的最佳度.
主要方法:
- 制备10%和20%的黑人树乙醇提取物膏.
- 在老鼠的切割皮肤伤口上涂抹药膏14或20天.
- 评估形态学,宏观学,组织学和生物化学参数.
主要成果:
- 黑色的提取物呈现出高和素含量,强烈的抗氧化活性 (DPPH,β-胡卜素漂白) 和抗炎性质 (LOX,COX抑制).
- 膏治疗显著增加了伤口收缩 (约. 97%),增强了抗氧化酶活性 (catalase,SOD),并减少了炎症标志物 (myeloperoxidase).
- 生物化学分析显示,氧和六胺水平增加,表明增强了原再生和组织修复. 组织学证实了改进的再上皮化和再血管化.
结论:
- 黑人油膏在老鼠中显示出显著的伤口愈合潜力.
- 发现,10%度的药膏是促进伤口愈合的最佳方法.
- 这些发现支持开发一种高效,天然的伤口治疗药物配方.
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