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Updated: Jun 26, 2025

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针对BIRC5作为一种治疗方法,以克服ASXL1相关的迪西抗性

Ming Yao1, Xiao Jiang2, Fangnan Xiao1

  • 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China; Tianjin Institutes of Health Science, Tianjin, 301600, China.

Cancer letters
|May 10, 2024
PubMed
概括

ASXL1突变降低了肌肉细胞癌症中对低甲基化剂的敏感性. 用YM-155与decitabine结合向BIRC5可能会克服这种抗药性,改善患者的治疗结果.

关键词:
美国证券交易所ASXL1在BIRC5中,有5个问题.对于德西塔的耐药性在YM-155中,YM-155是最常见的.

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