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在COVID-19和COVID-19疫苗接种后的亚急性甲状腺炎
Hadar Duskin-Bitan1, Eyal Robenshtok2, Alon Peretz3
1Endocrine Institute, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Division of Community Medical Services, Clalit Health Services, Tel Aviv, Israel.
概括
这项研究发现COVID-19感染或接种疫苗和亚急性甲状腺炎 (SAT) 之间没有联系. 对300万成年人的大规模分析表明,在COVID-19暴露或免疫接种后,SAT风险没有增加.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 报道称,COVID-19感染和疫苗接种与各种甲状腺疾病有关,包括亚急性甲状腺炎 (SAT).
- 了解潜在的关联对于公共卫生和临床管理至关重要.
研究的目的:
- 调查COVID-19感染和/或接种疫苗与亚急性甲状腺炎 (SAT) 的发展之间的关联.
主要方法:
- 一项大型队列研究,涉及从2020年3月到2022年9月期间由克莱利特健康服务公司保险的300万成年人.
- 确定了新的SAT诊断的患者,并与对照组进行了1:10的匹配.
- 多变量条件后勤回归模型分析了COVID-19暴露和SAT之间的关联.
主要成果:
- 总共有3221名SAT患者与32210名对照进行了匹配.
- 在诊断/指数日期前30,60或90天的SAT患者和对照人群之间,没有观察到COVID-19疫苗接种率 (任何剂量) 或感染率的统计学上显著差异.
- 在SAT患者中,甲状腺炎药物的使用率较高,包括NSAID,类固醇和β-阻断剂.
结论:
- 这项基于人口的大型研究没有发现COVID-19感染或COVID-19疫苗接种与亚急性甲状腺炎 (SAT) 的发展之间存在关联的证据.
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