在头到尾的身体轴形成过程中神经皮特征
C Martins-Costa1, V Wilson2, A Binagui-Casas2
1Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria.
Current topics in developmental biology
|May 10, 2024
概括
神经细胞皮原体 (NMP) 是脊椎动物身体轴发育的关键. 了解调节NMP命运的信号平衡对于发育生物学和临床应用至关重要.
科学领域:
- 发育生物学是发展生物学.
- 干细胞生物学 干细胞生物学
- 再生医学是一种再生医学.
背景情况:
- 脊椎动物体轴的发育依赖于胚胎后部的轴向祖先.
- 神经皮有能力细胞 (NMC) 或神经皮原生细胞 (NMP) 生成神经管和体.
- 由于其双重血统承诺,NMP具有显著的临床潜力.
研究的目的:
- 概述NMC/NMP中的信号传递和基因调控网络.
- 讨论中皮和神经命运决定的平衡.
- 要突出在轴前代维持和分化中研究较少的蛋白质.
主要方法:
- 对信号通路的审查 (Wnt/β-catenin,FGF,视网酸).
- 对转录因子调节的分析 (Brachyury, Sox2).
- 检查与轴性缺陷相关的突变表型.
主要成果:
- 维持NMP需要平衡Wnt/β-catenin,FGF和视网酸信号.
- 协同表达的Brachyury和Sox2保持了祖先的身份.
- 信号失衡导致中皮层或神经线条的损伤.
结论:
- 在NMP中实现间皮与神经命运平衡的精确机制尚未完全理解.
- 突变的表型表明,未表征的蛋白质在NMP功能中的作用.
- 对NMP调节的进一步研究可以促进发育生物学和再生医学的发展.
相关概念视频
Neurulation
41.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.9K
Gastrulation
57.3K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
57.3K
Determination
18.5K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
18.5K
Whole Body Regeneration
3.3K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.3K


