多烯胺在生理条件下通过对原的强化来改善键稳定性
Lincoln Borges1, Matthew Logan2, Samuel Weber2
1Oregon Health & Science University, Portland, OR, USA; Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
概括
多功能烯胺通过加强原和聚合物网络来增强粘合剂粘合稳定性. 这些牙材料减少了隙间的形成,并在像细菌生物膜这样的生理挑战下保持了结合强度.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 聚合物化学 聚合物化学
背景情况:
- 烯胺显示出提高粘合剂恢复稳定性的潜力.
- 牙粘合剂中烯胺的精确增强机制需要进一步阐明.
- 了解这些机制对于开发更持久的牙科修复至关重要.
研究的目的:
- 测试假设,蛋白和聚合物网络交叉连接的键增强有助于烯胺增强的键稳定性.
- 研究二级/三级烯胺在原网络增强中的作用.
- 为了评估二或三功能烯胺对聚合物网络交叉链接的影响.
主要方法:
- 两步全蚀刻粘合剂的配方,包含各种烯胺 (TAAEA,TMAAEA,BAAP,DEBAAP) 和一个控制 (HEMA).
- 在周期性机械和S. mutans生物膜挑战后,对隙形成和微拉伸键强度 (microTBS) 的评估.
- 通过氧胺测定和风湿学测量 (剪切模量) 评估原蛋白强化.
主要成果:
- 所有测试的单体均显示,在生物膜暴露后,间隙形成增加,键强度降低.
- 与HEMA对照组相比,三烯胺显著增加了微TBS.
- 多烯胺,除DEBAAP外,降低了原体降解副产品和增加了牙剪切模量,表明原体强化和改善了机械性能.
结论:
- 多功能烯胺有效地加强牙粘合剂中的原蛋白网络.
- 这些烯胺在生理条件下有助于减少间隙形成和稳定键强度.
- 这些发现支持在牙粘合剂修复中使用特定的多烯胺来提高耐用性.
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