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[2022年世界卫生组织细胞癌分类:专注于乳头细胞癌]

Sarah Bellal¹, Solène-Florence Kammerer-Jacquet², Nathalie Rioux-Leclercq²

¹Département de pathologie cellulaire et tissulaire, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France.

Annales de pathologie

|May 10, 2024

概括

2022年世界卫生组织分类将重新定义细胞癌 (RCC) 诊断,强调分子变化和ISUP分级,而不是以前的乳头亚型. 高度 papillary RCC (PRC) 现在是一种排除诊断,需要排除特定的分子亚型.

科学领域:

尿路病理学尿路病理学
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

细胞癌 (RCC) 呈现出显著的异质性,需要不断发展的分类系统.
2022年世界卫生组织 (WHO) 的分类引入了六个基于形态和分子变化的RCC类别.
乳头RCC (PRC) 的分类已经从1/2型转移到ISUP核分级.

研究的目的:

详细说明2022年更新的世界卫生组织细胞癌分类.
突出分子改变在识别新RCC实体的诊断影响.
强调对高度乳头皮质RCC的修订诊断标准.

主要方法:

审查最新的世卫组织2022年对细胞癌的分类指南.
对RCC亚型的分子变化 (FH缺乏,TFE3重新排列,TFEB变化) 的分析.
应用ISUP核分级用于乳头RCC分类.

主要成果:

2022年世界卫生组织分类将RCC基于形态学和分子发现进行分类.
通过分子分析识别新的RCC实体,如FH缺乏,TFE3重新排列和TFEB改变的RCC.
高度PRC现在是一种排除诊断,需要排除特定的分子亚型.

结论:

准确的RCC诊断需要了解基因组变化,并利用免疫组织化学或分子技术.
对中国的ISUP分级的转变简化了分类,并提高了预测准确性.
临床医生应考虑对PRC患者进行瘤遗传咨询,以选相关遗传瘤综合征.

关键词:

2022年世界卫生组织分类癌细胞酸盐酸酶缺乏.经过改变TFEB基因的再生癌症.增强或重新安排TFEB基因的再生癌.经过TFE3基因重组的再生癌.癌症性 rénal papillary 的癌症.分类 OMS 2022 年 OMS 2022 年缺乏酸盐酸酶的RCC.状细胞癌是状细胞癌.TFE3重新安排的RCC或TFEB改变的RCC.

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