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Masao Nakayama¹, Shuhei Sekii², Eiichi Miyazaki³

¹Division of Radiation Therapy, Kita-Harima Medical Center, Ono, Hyogo 675-1392, Japan; Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe City, Hyogo 650-0017, Japan; Discipline of Medical Radiations, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists

|May 10, 2024

概括

对于早期的喉腔癌,体积调制弧线疗法 (VMAT) 中的部分弧形门架角度可以增加计划目标体积 (PTV) 剂量,同时节省有风险的器官 (OAR). 然而,这些计划显示了更大的OAR剂量变化与定位错误.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
头部和部癌症治疗治疗

背景情况:

卷度调制弧线疗法 (VMAT) 是一种常见的放射治疗技术.
吊台旋转角度显著影响VMAT计划质量.
早期的喉癌需要精确的辐射输送,以平衡瘤控制和器官节约.

研究的目的:

为了比较VMAT中不同门旋转角度 (全,半,部分弧) 的剂量测量效应,用于早期的喉癌.
为了评估这些VMAT计划对位置错误的稳定性.
调查PTV特征与剂量变化之间的相关性.

主要方法:

对于22名早期喉癌患者,使用全,半和部分弧度生成了VMAT计划.
分析了规划目标体积 (PTV) 和风险器官 (OAR) 的剂量参数.
引入了位置移位 (1-5毫米),以评估计划的稳定性.
研究了与PTV大小,空气腔体积和光束路径长度的相关性.

主要成果:

与全弧和半弧相比,部分弧的VMAT计划实现了更高的PTV剂量 (D2%,D5%,D50%,D平均) 和更低的OAR剂量.
在定位错误下,部分弧图表表现出更大的OAR剂量变化.
PTV大小,空气腔体积和深度变化与PTV剂量变化存在相关性.

结论:

部分弧度VMAT提供了在PTV中剂量升级的潜力,同时避免了早期喉癌的OAR.
仔细考虑潜在的定位错误至关重要,因为OAR剂量变化增加了部分弧度.
PTV特征影响剂量变化,需要基于个体解剖学的计划优化.

关键词:

淋巴结膜癌是什么? 淋巴结膜癌是什么头癌是头部和部的癌症.强度调节的辐射疗法强度调节的辐射疗法.喉癌是一种喉癌.卷度调制弧形疗法是一种体积调制的弧形疗法.

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