由质形成的帕伦基马消灭:功能和瘤方面的影响
Akira Kazama1, Carlos Munoz-Lopez2, Worapat Attawettayanon3
1Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH; Department of Urology, Molecular Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Urologic oncology
|May 10, 2024
概括
在细胞癌 (RCC) 中,显著的辅酶体积置换 (PVR) 与较差的生存结果有关. 较高的PVR,特别是超过25%,独立预测癌患者的无复发生存率降低.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 脏瘤可以侵入并取代正常的脏组织.
- 通过细胞癌 (RCC) 进行实质性细胞体积替代 (PVR) 可能会影响生理结果.
- 之前对PVR的研究是有限的,需要使用先进的方法进行进一步的研究.
研究的目的:
- 评估PVR在患有非转移性脏瘤的患者中的瘤影响.
- 使用准确和客观的工具来量化PVR.
- 评估PVR和患者生存结果之间的关联.
主要方法:
- 追溯评估了1,222名患有非转移性瘤的患者,这些患者接受了部分或彻底切除术.
- 半自动化软件用于对子体体积分析,以估计功能分裂和手术前体积.
- 使用对照性脏作为对照,计算PVR%的计算,根据PVR程度分组患者:最小 (<5%),适度 (5%-25%) 和突出 (≥25%).
主要成果:
- PVR与手术前的双侧GFR相反相关,直接与晚期病理阶段,高瘤等级,清晰细胞组织学和瘤状特征相关.
- 显著的PVR (≥25%) 与缩短无复发,癌症特异性和整体存活时间有关.
- 男性性别,≥pT3a阶段,瘤4级,积极的手术边缘和PVR≥25%是减少无复发生存的独立预测因素.
结论:
- 通过RCC消除正常的膜细胞显著影响术前功能,并影响患者的选择.
- 增加PVR与瘤的攻击性特征有关.
- 较高的PVR独立地预测了无复发生存率的减少,因此需要进一步调查.
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