BNT162b2疫苗接种与免疫介导并发症发生率之间的关联
Michal Shani1, Irit Hermesh2, Ilan Feldhamer3
1Department of Family Medicine Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Family Medicine Central District, Clalit Health Service, Rehovot, Israel.
Vaccine
|May 10, 2024
概括
BNT162b2疫苗显示,罕见的自身免疫诊断风险增加,如牛皮,大肠炎和多肌痛类风湿症. 这些发现对于评估不同人群中疫苗的风险与益处很重要.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 全球针对SARS-CoV-2的疫苗接种活动于2020年12月开始.
- 需要进一步调查COVID-19疫苗接种的长期不良影响.
- 了解与疫苗相关的自身免疫诊断对于公共卫生至关重要.
研究的目的:
- 调查BNT162b2疫苗接种与新的自身免疫诊断之间的关联.
- 为了比较接种疫苗的人与未接种疫苗的人的自身免疫诊断率.
- 为了检查COVID-19感染作为自身免疫诊断的参考.
主要方法:
- 使用Clalit健康服务数据库进行回顾性队列研究.
- 在BNT162b2接种疫苗和未接种疫苗的个体之间,免疫介导诊断的比较.
- 在四个年龄组中应用了多变量考克斯回归模型与错误发现率校正.
主要成果:
- 接种BNT162b2疫苗与牛皮 (所有年龄段),大肠炎 (65岁以下),白风 (45-64岁) 和多发性肌痛风湿症 (≥65岁) 的风险增加有关.
- COVID-19感染与纤维肌痛 (18-64岁) 和甲状腺功能低下症 (≥65岁) 的风险增加有关.
- 危险比率 (HR) 表示疫苗接种后和感染后出现特定疾病的风险增加水平不同.
结论:
- BNT162b2疫苗与罕见的特定自身免疫疾病风险增加有关.
- 研究结果表明牛皮,大肠炎和多肌痛性风湿症是潜在的疫苗相关的免疫媒介诊断.
- 疫苗接种计划的风险效益评估应该考虑这些发现对不同人群的不同.
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