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化在肉瘤 (FUS) 抑制哺乳动物的牛奶生产效率

Haili Shao^1,2, Jipeng Huang^1,2, Hui Wang¹

¹National Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.

Nature communications

|May 10, 2024

概括

化在肉瘤 (FUS) 蛋白质通过防止乳腺细胞分化来抑制有效的乳生产. 这一发现解释了从 marsupials 到 eutherians 的牛奶生产进化,并对哺乳产生临床影响.

科学领域:

进化生物学进化生物学
哺乳动物生理学哺乳动物生理学
分子内分泌学分子内分泌学

背景情况:

高效的牛奶生产对于母婴能量传输和哺乳动物进化成功至关重要.
控制从有袋动物到类动物进化增加乳生产效率的调节机制尚不清楚.

研究的目的:

调查袋动物和eutherians之间的乳腺发育和牛奶生产效率差异的分子基础.
为了确定参与乳房效率进化建立的关键调节者.

主要方法:

在青春期,对袋鼠糖滑翔动物乳腺组成和发育进行比较分析.
使用小鼠模型研究化在肉瘤 (FUS) 蛋白在乳腺上皮细胞分化中的作用.
在哺乳期妇女中,FUS蛋白水平与乳生产的相关性分析.

主要成果:

袋鼠糖滑翔动物乳腺在青春期内含有牛奶成分,表现出比胎盘哺乳动物更不具动态的循环发育.
化在肉瘤 (FUS) 被确定为降低牛奶生产效率的一个因素.
在小鼠中,FUS通过p57Kip2抑制乳腺上皮细胞分化,导致哺乳失败;人类临床数据显示FUS水平与牛奶产量有负相关性.

结论:

融入肉瘤 (FUS) 作为乳腺功能和乳生产的负调节剂.
乳腺上皮细胞分化的FUS抑制提供了一个潜在的分子机制,解释了哺乳动物血统中乳生产效率的进化进展.

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