尿素感染30天死亡率,发病率及其风险因素: SERPENS研究,一个前性,观察性多中心研究
Zafer Tandogdu1,2, Bela Koves3, Slobodan Ristovski4
1University College London Hospitals, London, UK. drzafer@gmail.com.
World journal of urology
|May 10, 2024
概括
尿素感染死亡率为2.8%,风险因素包括并发症和多抗药性病原体. 识别这些因素对于更好的尿路感染管理和患者的治疗结果至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 尿路感染是一种严重的尿路感染,具有显著的死亡和发病风险.
- 了解早期的结果和风险因素对于有效的临床管理至关重要.
- 这项研究解决了需要更好地评估尿路感染 (UTI) 的严重程度的需求.
研究的目的:
- 为了描述30天的死亡率和发病率后的尿症诊断.
- 为了确定与尿路炎症患者不良结果相关的危险因素.
主要方法:
- 未来的观察性多中心队列研究 (2014-2018) 包括被诊断患有尿路的成年患者.
- 在30天后评估的结果:死亡,多器官衰竭,单个器官衰竭或恢复.
- 顺序逻辑回归分析用于识别风险因素.
主要成果:
- 30天死亡率为2.8% (严重败血症为4.6%).
- 84%的患者在30天内出现器官衰竭.
- 对不良结果的重大风险因素包括查尔森评分,呼吸衰竭,先前的ICU入院,阻塞,多药耐药病原体和SOFA评分≥2.
结论:
- 伴随性疾病和多抗药性病原体显著影响尿素感染的结果.
- 一个独特的患者群被确定为容易死亡和发病的.
- 需要开发实用分类来改善尿路感染严重性评估和管理.
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