抑郁症和焦虑对患有多发性硬化症的人的认知的影响:横截面分析
David E Freedman1, Jiwon Oh2, Alex Kiss3
1Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. david.freedman@sunnybrook.ca.
Journal of neurology
|May 10, 2024
概括
抑郁症和焦虑症在多发性硬化症 (MS) 患者中显著影响认知功能. 伴随性抑郁症和焦虑症与最严重的认知缺陷有关,这凸显了在MS治疗中需要综合心理健康护理的需要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床神经学 临床神经学
背景情况:
- 关于多发性硬化症 (MS) 中抑郁症,焦虑和认知功能障碍之间的关系存在相互矛盾的发现.
- 有限的研究已经探索了抑郁症和焦虑对MS相关认知障碍的联合影响.
研究的目的:
- 调查抑郁和焦虑症状升高之间的关联,单独和组合,与MS个体的认知功能.
- 确定伴随性抑郁和焦虑是否会加剧MS患者的认知功能障碍.
主要方法:
- 对831名多发性硬化症患者进行了横截面分析.
- 参与者完成了医院焦虑和抑郁量表 (抑郁症HADS-D,焦虑症HADS-A) 和MS认知功能的最小评估.
- 使用回归模型预测认知指数,控制相关的共变量.
主要成果:
- 抑郁症状独立地与口头流利,口头学习,口头延迟回忆和处理速度的缺陷有关.
- 焦虑,特别是在抑郁症患者中,预测视觉空间功能,口头学习,口头延迟回忆,视觉空间回忆和执行功能的下降.
- 单独的焦虑症状并未被发现在这个MS队列中独立预测认知障碍.
结论:
- 抑郁症是MS患者认知功能障碍的重要预测因素.
- 与抑郁症同时出现并发性焦虑症与更明显的认知障碍有关.
- 这些发现强调了解决抑郁症和焦虑症在MS认知问题的管理中的重要性.
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