在瘤患者中确定的MRONJ的临床状况 持续使用骨修饰剂
Elizabeth Miles1, Richa Arya2, Christopher Sproat3
1Specialist Registrar in Oral Surgery, Floor 23, Oral Surgery Department, Guy´s and St Thomas´ Hospital, London, SE1 9RT, UK.
British dental journal
|May 10, 2024
概括
在与药物相关的骨缩 (MRONJ) 患者中,持续使用骨修饰剂 (BMA) 似乎是安全的. 大多数患有确定的MRONJ的患者在服用BMA时表现为稳定或愈合的情况.
科学领域:
- 在瘤学瘤学.
- 牙科 牙科是指牙科的专业.
- 药理学 药理学是指药理学的学科.
背景情况:
- 与药物相关的骨 (MRONJ) 是骨修饰剂 (BMA) 的严重副作用.
- 已经建立的MRONJ的管理,特别是关于BMA的延续,缺乏强有力的证据.
- 牙医和瘤学家经常面临着关于BMA治疗MRONJ患者的困境.
研究的目的:
- 评估持续使用BMA对已确诊的与药物相关的骨硬化的临床状态的影响.
- 为在接受持续BMA治疗的患者中提供MRONJ进展的真实数据.
主要方法:
- 对29名已确诊的MRONJ癌症患者进行了回顾性审查,这些患者正在接受活跃的癌症治疗.
- 收集的数据包括人口统计,瘤状况,BMA史和MRONJ状态.
- 分析的重点是持续BMA治疗期间的MRONJ结果 (愈合,稳定或进展).
主要成果:
- 90%的确定的MRONJ患者在继续接受BMA时保持稳定或实现愈合.
- 69%的患者维持了MRONJ BMA前的治疗方案 (每三周或每四周服用一次剂量).
- 只有10.3%的患者经历了MRONJ的进展,其中两个患有新的死结部位.
结论:
- 继续使用骨修饰剂与大多数瘤患者的稳定或改善的MRONJ状态有关.
- 这项研究表明,对于所有已确诊的MRONJ.患者来说,药物假期可能并不必要.
- 现实世界的数据支持在接受活跃癌症治疗的MRONJ患者中继续使用BMA的安全性.
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