改变多层网络视角的灰色和白质连接在阻塞性睡眠呼吸暂停
Dong Ah Lee1, Ho-Joon Lee2, Kang Min Park3
1Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Sleep & breathing = Schlaf & Atmung
|May 10, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 在灰色和白质中显著改变大脑网络. 多层网络分析显示,与健康个体相比,OSA患者的连接模式不同,特别是在认知区域.
科学领域:
- 神经成像是一种神经成像.
- 网络神经科学 网络神经科学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍存在的睡眠障碍,具有已知的神经后果.
- 以前的研究表明,在OSA中大脑发生变化,但缺乏全面的网络层面分析.
研究的目的:
- 通过多层网络分析,研究阻塞性睡眠呼吸暂停 (OSA) 患者灰色和白质神经网络的变化.
- 为了比较OSA患者和健康对照者之间的网络特性.
主要方法:
- 招募了40名OSA患者 (通过多睡眠学) 和40名年龄/性别匹配的健康对照.
- 构建的灰色物质形态相似性网络 (T1加权成像) 和白色物质结构连接性网络 (扩散张力成像).
- 应用多层网络分析与图形理论来比较群体之间的网络指标.
主要成果:
- 在OSA患者和对照人群之间观察到全球网络指标的显著差异.
- OSA患者的平均重叠度和多层聚类系数较高,但多层模块化程度较低.
- 节点级分析揭示了与认知相关的大脑区域的明显的重叠程度差异.
结论:
- 多层网络分析有效地检测到OSA患者的显著灰色和白质变化.
- 观察到的网络变化,特别是在认知区域,突出显示了OSA对大脑结构和功能的影响.
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