克服抗生素耐药性:非热等离子体和抗生素组合抑制重要的病原体
Eva Vaňková1,2, Jaroslav Julák1,3, Anna Machková1
1Department of Physics and Measurements, University of Chemistry and Technology in Prague, 160 00 Prague, Czech Republic.
Pathogens and disease
|May 11, 2024
概括
抗生素耐药性是一个日益增长的威胁. 将非热等离子体 (NTP) 与抗生素 (ATB) 结合起来,在对抗耐药细菌和感染方面表现有前途,为应对这一全球卫生危机提供了一种新的战略.
科学领域:
- 微生物学 微生物学
- 医疗技术 医疗技术 医学技术
- 传染性疾病 传染性疾病
背景情况:
- 抗生素耐药性 (ATBR) 是一个关键的全球健康问题,预计到2050年将导致数百万人死亡.
- 新抗生素的开发落后于耐药病原体的兴起.
- 迫切需要采用替代策略来对抗抗生素耐药细菌引起的感染.
研究的目的:
- 审查关于非热等离子体 (NTP) 和抗生素 (ATB) 联合使用的实验研究.
- 评估NTP-ATB组合对抗抗药性病原体的浮游生物和生物膜生长的疗效.
- 在临床前模型中评估这种组合在治疗耐药细菌引起的感染方面的潜力.
主要方法:
- 对研究NTP-ATB组合的文献综述.
- 对抗美西林耐药性黄金葡萄球菌 (Staphylococcus aureus) 和空气菌 (Pseudomonas aeruginosa) 的抗菌活性实验数据的分析.
- 检查感染的体内小鼠模型的结果.
主要成果:
- 与单独治疗相比,NTP和ATB的组合显示出增强的功效.
- NTP-ATB组合有效抑制浮游生物细菌和生物膜的生长.
- 在小鼠模型中观察到由耐药病原体引起的感染的成功治疗.
结论:
- 非热等离子体和抗生素的组合是克服抗生素耐药性的有希望的策略.
- 这种方法提供了一种有效的解决方案,用于对抗由高度耐药的细菌引起的感染.
- 需要进一步的研究来探索NTP-ATB组合的全部治疗潜力.
相关概念视频
00:57Antibiotic Selection
53.2K
Overview
53.2K
01:27Combined Effects of Drugs: Synergism
3.9K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.9K
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:23Antimicrobial Proteins
982
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
982
01:29Methods of Sterilization I: Physical Methods
19.8K
As used in a healthcare facility, sterilization destroys all microorganisms through physical or chemical methods. The physical method includes steam, dry heat, boiling water, and radiation.
Steam sterilization uses non-toxic, low-cost moist heat in the form of saturated steam under pressure, which is fast, microbicidal, and sporicidal, and quickly warms and penetrates fabrics. Autoclaves, or steam sterilizers, expose each item to direct steam contact for a predetermined time at the necessary...
Steam sterilization uses non-toxic, low-cost moist heat in the form of saturated steam under pressure, which is fast, microbicidal, and sporicidal, and quickly warms and penetrates fabrics. Autoclaves, or steam sterilizers, expose each item to direct steam contact for a predetermined time at the necessary...
19.8K
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
371
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
371