在没有我的情况下重复它:通过ISMRM可重现性挑战众包T1映射共同点
Mathieu Boudreau1,2, Agah Karakuzu1, Julien Cohen-Adad1,2,3,4,5
1NeuroPoly Lab, Polytechnique Montréal, Montréal, Quebec, Canada.
Magnetic resonance in medicine
|May 11, 2024
概括
定量T1映射显示了研究小组之间的高变化,表明协议细节不足. 这一挑战凸显了对标准化MRI采集的需求,以实现可靠的体内测量.
科学领域:
- 磁共振成像技术 磁共振成像技术
- 量化MRI是指数量化的MRI.
- 生物医学工程 生物医学工程
背景情况:
- T1映射对于定量MRI至关重要,但在不同的协议,站点和供应商之间存在不一致的组织特异值.
- 复制性挑战阻碍了定量核磁共振技术的临床转化.
研究的目的:
- 评估标准反转恢复T1映射技术的可重现性.
- 为了评估T1测量在提交期间和提交期间的变异性,使用开创性论文的获取细节.
- 建立独立研究小组在体内T1变化的基线.
主要方法:
- 使用了来自Barral等人的采购协议. (2010) 用于T1映射.
- 在多个MRI供应商和场强度 (主要是3T) 上收集ISMRM/NIST幻影和人类大脑的数据.
- 采用开源平台进行数据提交,管道开发和分析,包括提交之间的和提交内的比较.
主要成果:
- 分析了18项提交 (39个幻影,56个人类数据集).
- 间提交的平均变化系数为6.1% (幻影) 和5.9% (人类基因),而内提交则为2.9% (幻影) 和3.2% (人类基因).
- 在人体皮质中观察到更高的变异性 (16%的介面,6.9%的内介面).
结论:
- 对于幽灵和人类大脑来说,T1间提交变异性是内部提交变异性的两倍.
- 最初的采购细节对于可重复的定量MRI协议来说是不够的.
- 这项研究量化了T1测量的固有不确定性,为未来的临床标准化工作提供了信息.
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