在肝细胞癌的跨动脉化学栓塞之前短期服用伦瓦替尼的效果
Tetsuya Tachiiri1, Kiyoyuki Minamiguchi1, Ryosuke Taiji1
1Department of Diagnostic and Interventional Radiology, Nara Medical University, Kashihara 634-8522, Japan.
Cancers
|May 11, 2024
概括
短期的伦瓦替尼布加上跨动脉化学栓塞 (TACE) 是对肝细胞癌 (HCC) 的可行且安全的治疗方法. 这种方法显示出有希望的结果,包括高完全响应率和HCC患者的延长无进展生存期.
科学领域:
- 肝胆瘤学 肝胆瘤学
- 干预性放射学是干预性的放射学.
- 医学瘤学 医学瘤学
背景情况:
- 肝细胞癌 (HCC) 是一种主要的肝脏恶性瘤.
- 跨动脉化学栓塞 (TACE) 是针对HCC的标准局部治疗方法.
- 伦瓦提尼布是一种具有抗血管原性质的多向氨酸激酶抑制剂.
研究的目的:
- 在4天的伦瓦提尼布治疗后评估瘤血液动力学.
- 为了评估短期的伦瓦提尼布-TACE (LEN-TACE) 协议对不可切除的HCC的治疗结果.
- 确定组合方法的可行性和安全性.
主要方法:
- 总共有25名无法切除的HCC患者接受了4天的伦瓦提尼布 (4-12毫克),其次是TACE.
- 输液CT扫描用于评估lenvatinib之前和之后的瘤内血流.
- 治疗包括传统的TACE (cTACE) 或药物释放珠子TACE (DEB-TACE).
主要成果:
- 伦瓦提尼布显著减少了瘤内血流 (p < 0.05).
- 总体完整反应 (CR) 率为75% (84%为cTACE,40%为DEB-TACE).
- 12个月无进展生存率 (PFS) 为75.0%,没有严重不良事件.
结论:
- 短期LEN-TACE是HCC的可行和安全治疗方法.
- 该协议显示出有希望的结果,包括高CR率和延长PFS.
- 需要进一步的前性临床试验来确认这种治疗策略的好处.
更多相关视频
09:49Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
Published on: December 2, 2013
10.3K
08:55Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
Published on: April 15, 2016
9.5K
相关概念视频
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
155
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
155
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K