用免疫检查点封锁治疗的高等级形瘤:MD安德森癌症中心的经验
Lewis F Nasr1, Marianne Zoghbi1, Rossana Lazcano2
1Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cancers
|May 11, 2024
概括
免疫检查点阻塞 (ICB) 显示出对先进的无差异化形肉瘤 (UPSs) 的前景,32%的6个月无进展生存率 (PFS). 现实世界的数据表明可管理的毒性和部分或稳定的响应者改善了结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 肉瘤研究研究 肉瘤研究
背景情况:
- 不分化的多形瘤 (UPSs) 是常见的软组织瘤.
- 有限的现实世界的数据存在于免疫检查点阻塞 (ICB) 在UPS和其他高等级形肉瘤的疗效.
研究的目的:
- 评估ICB在高级UPS和其他高等级形肉瘤中的疗效和毒性.
- 描述一个单一机构的现实结果.
主要方法:
- 这是一项追溯的观察性研究,对36名患有转移性形肉瘤的患者进行了ICB治疗.
- 2015年1月至2023年1月期间从MD安德森癌症中心收集的数据.
- 排除未发表的临床试验中的患者.
主要成果:
- 无进展生存 (PFS) 的中位数为2.9个月;6个月的PFS为32%.
- 平均整体存活 (OS) 为12.9个月;24个月的OS为29%.
- 最好的反应,先前的放射治疗和ICB类型影响了PFS;毒性是可控的.
结论:
- 现实世界的数据支持ICB疗效,其6个月PFS为32%.
- 实现部分或稳定反应的患者表现出明显改善的PFS.
- ICB是一种可行的治疗选择,可用于高级形肉瘤的可控毒性.
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