交叉性,BRCA遗传测试和家族内部风险沟通:一种定性研究
Sharlene Hesse-Biber1, Memnun Seven2, Hannah Shea1
1Department of Sociology, Boston College, Chestnut Hill, MA 02467, USA.
Cancers
|May 11, 2024
概括
了解BRCA基因检测和风险沟通的障碍对不同人群至关重要. 需要量身定制,文化敏感的方法来减少基因组医疗保健中的健康差异.
科学领域:
- 基因组医学是基因组医学.
- 健康差距 研究 研究 研究 研究
- 质量健康研究 质量健康研究
背景情况:
- 显著的健康差异与BRCA1/2基因中的致病变体有关.
- 现有的研究往往忽视了种族和种族多样化的人口接受基因测试的经验.
- 基因风险的家族内部沟通在不同社区中提出了独特的挑战.
研究的目的:
- 在不同个体中探索BRCA1/2基因测试的障碍和促进因素.
- 了解BRCA1/2遗传风险的家族内传播的复杂性.
- 为精准医疗保健提供以人为中心,文化敏感的方法,并减少基因组差异.
主要方法:
- 对非西班牙裔白人 (n=11) 和黑人,土著,有色人种 (BIPOC) 个人 (n=14) 进行了定性采访,测试了致病性BRCA1/2变体.
- 模板分析用于识别个人,人际关系和医疗保健系统层面的关键因素.
- 一个分为两部分的案例研究分析检查了种族/种族,文化,社会经济地位和系统不平等的交叉点.
主要成果:
- 个人因素 (心理社会福祉),家庭动态和医疗保健系统的经验显著影响遗传测试和风险沟通.
- 种族/种族,文化规范和社会经济地位与系统不平等相互作用,加剧了基因组医疗保健中的差异.
- 由于个人,家庭和结构因素的相互作用,BIPOC个体面临复杂的挑战.
结论:
- 迫切需要以人为中心,量身定制和文化敏感的策略来应对BRCA测试和风险沟通方面的挑战.
- 跨界方法对于理解和消除基因组医疗保健中现有的差异至关重要.
- 实施这些量身定制的方法可以带来更公平的精确医疗保健结果.
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