发炎与结肠癌风险增加有关 - 全国基于登记册的队列研究
Laura Quitzau Mortensen1,2, Kristoffer Andresen1, Lau Thygesen3
1Center for Perioperative Optimization, Department of Surgery, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark.
Journal of clinical medicine
|May 11, 2024
概括
被诊断出患有分歧炎的患者在六个月内患结肠癌的风险增加. 然而,观察到长达八年的保护作用,这表明随访结肠镜检查可能有查益处.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 关于分炎和结肠癌之间的关联,存在相互矛盾的证据.
- 不同的临床指导方针在分泌炎发作后推不同的随访结肠镜检查方案.
- 研究管炎患者的结肠癌风险对于完善后续策略至关重要.
研究的目的:
- 为了确定患有分炎的患者是否面临患结肠癌的风险增加.
- 提供基于证据的建议,用于分泌体炎后的结肠镜监测.
主要方法:
- 一项全国性的队列研究,利用1995-2013年间的丹麦链接登记册.
- 潜炎病例的纳入期:1997年至2009年.
- 用随时间变化的共变量进行考克斯回归分析,以估计结肠癌风险,包括先前结肠镜检查患者的敏感性分析.
主要成果:
- 分析了一组29,173名白炎患者和145,865名匹配的对照组.
- 结肠癌发病率在分泌炎组为2.1%,对照组为1.5% (HR 1.6).
- 在0-6个月内观察到结肠癌的风险增加 (HR1.7),随后保护作用长达8年 (HR0.8).
结论:
- 发炎的诊断与在前六个月内显著增加结肠癌风险有关.
- 潜在的查效应导致结肠癌风险降低,诊断后长达八年.
- 在初始诊断分泌体炎后,建议进行常规的随访结肠镜检查.
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