通过电阻负荷诱导的轻度过渡性呼吸系统损伤期间功能连接的改变
Akiko Yorita1, Tomotaka Kawayama1, Masayuki Inoue2
1Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.
Journal of clinical medicine
|May 11, 2024
概括
轻度呼吸障碍会改变大脑的连接,特别是在感官和视觉网络. 前半岛和尾极之间的连接性增加与喘息相关,这表明呼吸感知有新的神经机制.
科学领域:
- 神经成像是一种神经成像.
- 呼吸系统生理学 呼吸系统生理学
- 功能连接的功能连接性
背景情况:
- 之前的研究已经确定了用于呼吸控制和感知的大脑区域.
- 呼吸障碍中的休息状态功能连接 (FC) 仍未得到充分研究.
- 这项研究研究了轻度呼吸障碍的FC,而不会影响氧和度.
研究的目的:
- 为了确定与轻度呼吸障碍相关的静止状态功能连接 (FC).
- 为了探索神经机制,底层的呼吸困难的感觉.
主要方法:
- 来自36名健康志愿者的休息状态功能磁共振成像 (fMRI) 数据.
- 由于电阻负荷 (努力呼吸) 引起的轻度呼吸障碍.
- 使用SPM12和CONN工具箱进行ROI-to-ROI和seed-to-voxel分析.
主要成果:
- 与正常呼吸相比,努力呼吸在感官感知和视觉皮质区域内和之间激活了FC.
- 图形理论分析揭示了视觉皮层的强烈中心性.
- 发现呼吸障碍得分和左前胰岛和右尾极之间的FC之间存在正相关性.
结论:
- 通过网络枢纽,呼吸道感官区域内的功能连接可能是呼吸力和喘息感知的基础.
- 研究结果表明,视觉网络在轻度呼吸系统障碍中起着作用.
- 确定的神经机制提供了关于呼吸道感官处理的见解.
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