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基于经过验证的医生全球评估 (PGA) 评分,探索白风中疾病活动和再发色的严重程度层

Nanja van Geel¹, Liesbeth Delbaere¹, Laura Mertens²

¹Department of Dermatology, Ghent University Hospital, 9000 Ghent, Belgium.

Journal of clinical medicine

|May 11, 2024

概括

本研究建立了白风活动和改善的全球评估标准,使用医生全球评估 (PGA) 来分层像VESplus和VDAS/VDIS这样的得分. 这些发现将有助于在国际上标准化白风病监测.

科学领域:

皮肤病学皮肤病学
临床研究临床研究
医学评估医学评估

背景情况:

缺乏用于解释全球白风病活动 (恶化) 和再发色 (改善) 的标准化指导.
最近验证了白病活动评分 (VDAS15&60) 和白病改善评分 (VDIS15&60) 的动态评估.

研究的目的:

评估医生全球评估 (PGA) 对白风活动和改善的有效性和可靠性.
通过ROC分析将现有的白风得分 (VESplus,VDAS15&60,VDIS15&60) 分为全球类别 (略微,中度,更糟/更好).

主要方法:

医生全球评估 (PGA) 用66名患者的照片集评估了构造有效性和inter/intrarater可靠性.
用于确定分层VESplus,VDAS15&60和VDIS15&60成全球类别的截止值的ROC分析.

主要成果:

对于"更差"和"更好"类别的VESplus (BSA百分比变化) 的确定的截止值.
定义了VDAS15 (身体活跃区域) 和VDIS15的"更差"和"更好"分类的最佳截止值.
确定VDAS60和VDIS60的切线点,并注意广泛白风患者的谨慎.

结论:

该研究为解释全球白风活动和改善程度的解释提供了一个框架.
这些发现支持制定更详细的国际定义,用于白风病监测.

关键词:

活动活动活动活动活动活动.测量仪器是一种测量仪器.结果结果结果结果.医生报告的结果.分层分层是分层的分层.在白风,白风.

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