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用bDMARDs治疗的炎症关节病患者脉冲波变化的初步研究

Michela Gasparotto^1,2, Giuliano Di Pierro³, Barbara Toffoli³

¹UCO Medicina Clinica, ASUGI, Cattinara Teaching Hospital, Strada di Fiume 447, 34149 Trieste, Italy.

Journal of clinical medicine

|May 11, 2024

概括

生物技术疾病修饰药物 (bDMARDs) 改善了心血管健康标志物,如结性脊髓炎和类风湿关节炎患者的脉冲波速度. 然而,牛皮关节炎患者没有表现出类似的改善.

科学领域:

心血管医学心血管医学
类风湿病学类风湿病学
药理学药理学是指药理学的学科.

背景情况:

患有炎症性关节病的患者心血管疾病 (CVD) 风险增加,标准得分无法完全捕捉到.
生物技术疾病修饰药物 (bDMARDs) 降低了心血管疾病风险,但心血管疾病仍然是严重的死亡原因.
脉冲波的参数,特别是动脉-大腿脉冲波速度 (cfPWV),可以预测心血管疾病风险.

研究的目的:

在接受bDMARD治疗的炎症关节病患者中评估脉冲波参数的变化.
评估bDMARDs对结性脊髓炎 (AS),牛皮关节炎 (PsA) 和类风湿性关节炎 (RA) 的动脉硬性的影响.

主要方法:

平度测量用于测量AS,PsA和RA患者的脉冲波参数.
在bDMARD治疗两年之前和之后进行了测量.
统计分析将cfPWV与年龄,C反应蛋白 (CRP) 和健康评估问卷-残疾指数 (HAQ) 相关联.

主要成果:

基线cfPWV与年龄相关;下内心活力比率与CRP和HAQ负相关.
在PsA患者中,男性患病率较高,CRP升高,基线最高的cfPWV.
两年后,脉冲波参数在AS和RA患者中得到改善,但在PsA患者中没有改善.

结论:

脉冲波参数显示在AS和RA中使用bDMARD治疗的潜在可逆性.
在PsA患者中缺乏改善可能与更高的男性比例和基线cfPWV有关.
动脉硬性变化需要在用bDMARDs治疗的炎症性关节病中进行进一步的研究.

关键词:

大动脉硬性大动脉硬动脉度计是动脉度计.关节炎是一种关节炎.心血管疾病的风险.系统性炎症系统性炎症

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