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结构性表征的多边形Cyrtonema多糖和其对巨细胞的免疫调节作用

Ruiding Wen¹, Lu Luo¹, Runcheng Zhang¹

¹TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

Molecules (Basel, Switzerland)

|May 11, 2024

概括

来自Polygonatum cyrtonema (NPCP) 的中性多糖化物调节巨细胞的活性,增强细胞增殖和细胞化,同时平衡炎症反应. 这表明NPCPP是NPCP.

科学领域:

自然产品化学自然产品化学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

聚糖类 (PCP) 已知具有各种生物活性.
了解特定PCP的免疫调节作用对于治疗开发至关重要.

研究的目的:

为了隔离,净化和表征从Polygonatum cyrtonema (NPCP) 中的中性多糖体.
研究NPCP对巨细胞的体外免疫调节作用.

主要方法:

使用DEAE-52和Sephadex-G100染色学进行隔离和净化.
通过HPLC,HPGPC,GC-MS,FT-IR,NMR和SEM进行结构性表征.
在体外生物活性测定对巨细胞,包括增殖,细胞和细胞因子分泌分析.

主要成果:

NPCP是一种中性多糖体 (3.2 kDa),由葡萄糖 (55.4%) 和银糖 (44.6%) 组成,具有特定的葡萄糖酸链接.
NPCP增强了巨细胞的增殖和细胞化.
NPCP抑制了M1和M2巨细胞的两极分化和调节的细胞因子分泌,抑制IL-6和TNF-α,同时促进IL-10.

结论:

NPCP具有显著的免疫调节特性.
通过平衡巨细胞极化和细胞因子概况,NPCP显示出作为抗炎剂的潜力.

关键词:

这种植物名为Polygonatum cyrtonema.免疫调节活性免疫调节活性聚糖是一种多糖.结构特征结构的描述.

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