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揭示纳米配方红藻提取物在癌症管理中的作用

Gopalarethinam Janani¹, Agnishwar Girigoswami¹, Balasubramanian Deepika¹

¹Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chettinad Health City, Kelambakkam, Chennai 603103, India.

Molecules (Basel, Switzerland)

|May 11, 2024

概括

海藻提取物,制成脂质体 (NHA),显示显著的抗癌活性对A549细胞. 这种NHA配方在斑马鱼模型中也显示出出色的生物相容性,表明其作为一种新型癌症治疗药物的潜力.

科学领域:

海洋生物技术海洋生物技术
癌症治疗方法癌症治疗方法
药物输送系统药物输送系统

背景情况:

癌症仍然是全球主要的死亡原因,化疗由于严重的副作用而表现出显著的限制.
对于新型,生物相容的治疗药物来克服与常规癌症治疗相关的挑战,有着至关重要的需求.
海洋藻类拥有多种生物活性化合物,具有潜在的治疗应用,包括抗氧化和抗癌特性.

研究的目的:

合成和表征海藻*Amphiroa anceps*的水性提取物 (HA),并将其配制成脂质体输送系统 (NHA).
为了评估NHA在体外对A549肺癌细胞的抗癌疗效.
使用斑马鱼模型评估HA和NHA的体内生物相容性和安全性.

主要方法:

来自*Amphiroa anceps*的水性提取物 (HA) 和随后的脂质体配方 (NHA) 的合成.
使用动态光散射,UV可见光谱,FTIR,扫描电子显微镜 (SEM) 和GC-MS分析进行提取物的表征.
使用A549细胞进行体外抗癌活性评估和斑马鱼体内生物相容性研究.

主要成果:

在SEM分析中,NHA粒子大小在112-185nm之间.
GC-MS分析显示,八甲酸和n-六甲酸是主要成分.
NHA证明了A549癌细胞的剂量依赖抑制,在100μg/mL时达到92%的细胞杀伤,在斑马鱼中没有观察到致病作用.

结论:

*Amphiroa anceps*提取物的脂质体配方 (NHA) 在体外表现出强大的抗癌活性.
在有效度下,NHA表现出良好的生物相容性,在体内没有任何不良影响.
NHA代表了开发一种新型,生物相容的癌症治疗剂的有希望的候选人.

关键词:

阿姆菲罗亚的前端 (anceps)它具有抗癌活性,具有抗癌活性.细胞活力的细胞活力.纳米制剂的纳米配方斑马鱼胚胎斑马鱼的胚胎

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