基板NMR与化学测量相结合:一种工作流程,揭示蜂蜜补充剂中隐藏的药物成分
Camille Pujol1, Saïda Danoun2, Ghislaine Biasini3
1Laboratoire Softmat, Université de Toulouse, CNRS UMR 5623, Université Toulouse III-Paul Sabatier, 31062 Toulouse, France.
Molecules (Basel, Switzerland)
|May 11, 2024
概括
基板核磁共振 (NMR) 与化学测量相结合,有效地选蜂蜜补充剂的tadalafil和sildenafil等 adulterants. 该方法准确地识别和量化食品补充剂中未申报的活性药物成分.
科学领域:
- 分析化学 分析化学
- 食品科学 食品科学 食品科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 基板核磁共振 (NMR) 光谱仪提供了可访问的分析能力.
- 化学测量方法增强了NMR光谱的数据分析.
- 食品补充剂与活性药物成分的改对健康构成重大风险.
研究的目的:
- 开发和验证一种选方法,用于伪造的蜂蜜食品补充剂.
- 使用基板NMR光谱仪与化学测量相结合,用于检测制药造物.
- 为了识别和量化特定的伪造剂,即tadalafil和sildenafil.
主要方法:
- 分析50个蜂蜜补充剂样本,使用60MHz基板NMR光谱仪进行分析.
- 化学测量模型的应用,包括部分最小平方差分分析 (PLS-DA) 用于分类.
- 部分最小方程 (PLS) 回归的利用用于伪造物的定量分析.
主要成果:
- 在37个样本中检测出tadalafil,在5个样本中检测出sildenafil.
- 在一个样本中识别了flibanserin和tadalafil的组合.
- 成功地将样品分类为 adulterated 或非 adulterated 的高度准确性.
结论:
- 拟议的NMR-化学计量工作流提供了一种高效可靠的选蜂蜜补充剂的方法.
- 这种方法可以检测和量化未申报的活性药物成分.
- 该研究强调了基准NMR在监管控制和消费者保护方面的潜力.
关键词:
伪造 伪造 伪造基板NMR可以使用.化学测量方法 化学测量方法紧的NMR是指一个紧的NMR.蜂蜜,蜂蜜,蜂蜜,蜂蜜,蜂蜜,蜂蜜,蜂蜜低场NMR是一种低场NMR.这种药物是西尔代纳菲尔.塔达拉菲尔 (tadalafil) 的使用情况更多相关视频
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