由于紧张结口表达的变化而改变的汗液组成 汗腺在胆固醇性疹患者的表达
Denisa Daci1, Sabine Altrichter2,3,4,5, François Marie Grillet2,3
1Clinical Physiology/Nutritional Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 12203 Berlin, Germany.
International journal of molecular sciences
|May 11, 2024
概括
胆性疹 (CholU) 涉及热量引发的状疹. 这项研究发现,CholU患者的汗腺功能和电解质变化发生了改变,这表明汗液生产能力下降.
科学领域:
- 皮肤病学 皮肤病学
- 生理学 生理学 生理学
- 免疫学 免疫学 免疫学
背景情况:
- 胆固醇性疹 (CholU) 的特点是热引起的疹,并报告出汗减少.
- 尽管有涉及减少肌肉蛋白受体,汗道阻塞或汗液过敏的理论,但CholU的精确潜在机制仍然不太清楚.
研究的目的:
- 通过检查汗腺的功能和结构来研究胆性疹的病理机制.
- 分析汗液成分,并探索CholU患者的紧结蛋白的表达.
主要方法:
- 从CholU患者和健康对照组中收集了皮肤活检和汗水样本,在运动和桑拿挑之前和之后.
- 在皮肤活检中利用免疫组织化学分析dermcidin和紧结蛋白分布 (claudin-3,-10b,occludin,zonula occludens-1).
- 建立了一个ex vivo皮肤模型来量化汗液分泌量.
主要成果:
- CholU患者表现出明显减少局部出汗,但总出汗量没有变化.
- 在CholU患者的汗水中观察到K+度升高.
- 在汗腺的分泌线圈中观察到紧结蛋白claudin-3,claudin-10b和ocludin的分布变化,而 zonula occludens-1保持不变. 皮肤色素染色证实其位于汗腺内.
结论:
- 这些发现表明皮肤屏障完好无损,但CholU患者的汗水产生能力降低.
- 改变的汗液电解质组成和紧结蛋白分布指向局部化汗腺功能障碍.
- 开发的ex vivo皮肤模型为进一步调查CholU病理机制和汗腺功能提供了一个平台.
相关概念视频
01:28Cholinergic Antagonists: Pharmacological Actions
1.1K
Antimuscarinic drugs block muscarinic receptors in multiple systems, including the gut, eye, smooth muscles, respiratory tract, cardiovascular, and central nervous systems. They produce similar effects with varying selectivity depending on the specific agent and tissue. Here are the key pharmacological actions of antimuscarinics:
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
1.1K
00:59Direct-Acting Cholinergic Agonists: Pharmacological Actions
1.3K
Direct-acting cholinergic agonists exert their pharmacological actions by mimicking the effects of acetylcholine on postsynaptic muscarinic receptors to generate parasympathetic responses. These agents elicit a range of physiological responses, including cardiovascular effects. For example, activation of muscarinic receptors induces bradycardia, decreased cardiac output, reduced peripheral resistance, and consequent hypotension. In the eye, stimulation of M3 receptors leads to smooth muscle...
1.3K
01:24Cholinergic Antagonists: Pharmacokinetics
435
Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations, while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...
435
01:29Tight Junctions
5.3K
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
5.3K
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
661
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
661
01:25Cholinergic Receptors: Muscarinic
2.1K
The pharmacological actions of acetylcholine are elicited via its binding to two families of cholinergic receptors or cholinoceptors, namely, muscarinic and nicotinic receptors. Muscarinic receptors are G protein-coupled receptors and have five subtypes, M1–M5. All mAChR subtypes are activated by acetylcholine and blocked by the antagonist, atropine.
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+....
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+....
2.1K