一种基于益生菌的创新补充剂,以减轻与抑郁和焦虑有关的分子因素:一个体外研究
Sara Ferrari1, Simone Mulè1, Giorgia Rosso1
1Laboratory of Physiology, Department for Sustainable Development and Ecological Transition, 13100 Vercelli, Italy.
International journal of molecular sciences
|May 11, 2024
概括
这项研究表明,特定的益生菌可以积极影响肠道屏障和短链脂肪酸生产. 这些益生菌还可以防止焦虑和抑郁,而不会造成伤害.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 肠-大脑轴描述了肠道微生物群和大脑之间的双向通信.
- 新兴研究探讨了肠道微生物群在人类行为,大脑发育和功能中的因果作用.
- 益生菌已经显示出降低焦虑和抑郁症状的潜力.
研究的目的:
- 研究一种新的益生菌配方对控制焦虑和抑郁的途径的影响.
- 在3D模型中评估配方对肠道屏障活动的影响.
- 为了确定配方是否有有害的副作用.
主要方法:
- 利用一个3D体外模型来测试益生菌组合.
- 评估了肠道屏障功能的调节和短链脂肪酸合成.
- 评估了益生菌对神经元损伤的影响以及L-谷氨酸诱导的焦虑/抑郁模型.
主要成果:
- 一个B. B. B. B. 双体新型BBF7,B. 双体新型BBF7,B. 新BLG2和L.L.L.L.L.L.L.L.L.L.L.L.L.L.L. paracasei TJB8 影响了肠道屏障,并增强了短链脂肪酸的合成.
- 研究的益生菌没有诱导神经元损伤.
- 益生菌组合证明了对L-谷氨酸诱发的焦虑和抑郁的保护作用.
结论:
- 益生菌可以调节肠道功能,以影响焦虑和抑郁的基础路径.
- 这种新型的益生菌配方通过准肠-大脑轴,显示出对管理焦虑和抑郁症状的希望.
- 对心理健康状况的益生菌干预措施进行进一步的研究是有必要的.
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