权衡利益和风险:关于对人类G-CSF (粒细胞殖民地刺激因子) 的过敏反应的文献综述
Roxana Silvia Bumbăcea1,2, Mihaela Ruxandra Udrea1,2, Selda Ali1,2
1Allergology Department, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
International journal of molecular sciences
|May 11, 2024
概括
对颗粒细胞殖民地刺激因子 (G-CSF) 的过敏反应 (HRs) 是罕见的,但可能严重. 这项研究系统地审查了G-CSF诱导的HRs,发现了即时和延迟反应,其中一些发生在第一次暴露后.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 颗粒细胞殖民地刺激因子 (G-CSF) 对于治疗中性衰竭至关重要.
- 对G-CSF的过敏反应 (HRs) 很少报告,流行率不明.
- 描述G-CSF诱导的HRs对于患者安全和治疗优化至关重要.
研究的目的:
- 系统地描述G-CSF诱导的过敏反应 (HR).
- 编制与G-CSF相关的不良反应的全面列表.
- 评估G-CSF诱导的HRs的流行率和特征.
主要方法:
- 对PubMed,Embase,Cochrane图书馆和Web of Science数据库进行系统的文献审查.
- 使用相关关键词对2024年1月之前发表的文章进行搜索.
- 从17篇相关文章和7个额外来源提取数据,共计40例G-CSF诱导的HRs.
主要成果:
- 确定了40例G-CSF诱导的HRs,分类为立即 (29) 或延迟 (11).
- 经常与菲尔格拉斯蒂姆相关的即时反应包括严重的过敏反应 (9例,WAO级5级).
- 延迟反应,主要是黄斑斑块外,允许G-CSF的延续;在第一次暴露后发生了11例.
结论:
- 虽然很少见,但G-CSF诱导的HRs可能是严重的,并在治疗早期发生.
- 需要进一步的研究和定期更新,以充分理解和管理G-CSF引起的HRs.
- 存在有限的脱敏协议,突出需要改进的管理策略.
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