具有异卵性家族高胆固醇血症的弹性老年患者,基线差异和相关因素
Elisenda Climent1, Antón González-Guerrero2, Victoria Marco-Benedí3
1Lipid and Vascular Risk Unit, Department of Endocrinology and Nutrition, Hospital del Mar, 08003 Barcelona, Spain.
患有家族性高胆固醇血症 (HeFH) 的老年人抵抗动脉样硬化心血管疾病 (ACVD),具有更高的HDL胆固醇和更低的脂蛋白[Lp[a]]. 这些因素,以及较少的并发症,有助于抵御ACVD的弹性.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 脂质学 脂质学是指脂质学.
背景情况:
- 家庭性高胆固醇血症 (HeFH) 的特征是低密度脂蛋白 (LDL) 胆固醇的升高.
- 尽管LDL高,但一些HeFH患者表现出对动脉样硬化心血管疾病 (ACVD) 的弹性.
- 导致这种弹性因素的理解尚不完全.
研究的目的:
- 为了确定与ACVD和没有ACVD的老年HeFH受试者之间的差异性特征.
- 确定与该人群中ACVD存在相关的因素.
主要方法:
- 来自西班牙动脉样硬化学会失脂症登记册的数据分析.
- 包括70岁及以上的HeFH受试者.
- 基线特征的比较和多变量分析以确定ACVD预测因素.
主要成果:
- 弹性受试者 (没有ACVD) 主要是女性,年轻,并具有较少的并发症.
- 没有ACVD的受试者显示高密度脂蛋白 (HDL) 胆固醇较高 (55.8比47.9毫克/分升).
- 没有ACVD的受试者具有较低的脂蛋白 (a) [Lp (a) ]水平 (53.4比66.6 mg/dL).
- 升高的Lp (a) 和存在三种或更多的风险因素与ACVD有关.
结论:
- 脂蛋白水平和心血管风险因素的数量是老年HEFH患者中ACVD的关键决定因素.
- 在这个队列中,较高的HDL胆固醇和较低的Lp (a) 与保护ACVD有关.
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