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基于血液的表观遗传年龄加速和发生结肠直肠癌的风险:基于人口的病例对照研究的发现

Sofia Malyutina¹, Olga Chervova², Vladimir Maximov¹

¹Research Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics SB RAS, Novosibirsk 630089, Russia.

International journal of molecular sciences

|May 11, 2024

概括

通过DNA甲基化测量加速表观遗传年龄 (EAA) 与增加结直肠癌 (CRC) 风险有关. 在一项基于人群的研究中,六个EAA标志物中的四个显示出与较高的CRC发病率有显著的关联.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
癌症流行病学癌症流行病学
生物标志物生物标志物

背景情况:

表观遗传衰老加速 (EAA) 反映了生物衰老,并可能影响与年龄相关的疾病风险.
结肠直肠癌 (CRC) 是一个重要的公共卫生问题,具有复杂的风险因素.
了解CRC风险的新生物标志物对于早期检测和预防至关重要.

研究的目的:

调查各种表观遗传衰老加速 (EAA) 措施与发生结直肠癌 (CRC) 的风险之间的关联.
确定特定的表观遗传衰老时钟是否可以预测一般人群未来的CRC诊断.

主要方法:

在HAPIEE队列中采用了嵌套病例控制研究设计,包括9360名参与者,持续16年.
用DNA甲基化数据计算了六种不同的表观遗传年龄 (EA) 尺度及其相应的表观遗传年龄加速 (EAA).
进行了统计分析,包括赔率比率 (OR) 和置信区间,以评估EAA和CRC风险之间的关系,并根据相关因素进行调整.

主要成果:

四个EAA测量 (Horvath,Hannum,PhenoAge和BLUP) 显示出与事件CRC风险的显著正相关性 (ORs在每分数增加1.20至1.44之间).
两个EAA测量 (皮肤和血液 (SB) 和弹性网 (EN)) 显示出与CRC风险的边界反向关联 (ORs为0.86-0.87).
第三级分析证实了四个EAA措施的积极关联,以及ENEAA的适度反向关联.

结论:

加快表观遗传衰老,正如四个特定标记所示,与发生结直肠癌的风险增加有关.
这些发现表明,某些表观遗传年龄测量可以作为CRC风险分层的潜在生物标志物.
需要在更大的潜在队列中进行进一步的验证,以确认这些关联并探索CRC预防的临床影响.

关键词:

通过DNA甲基化.这就是HAPIEE项目.年龄化的衰老.案例控制情况结肠直肠癌是什么意思表观遗传年龄表观遗传年龄人口人口人口的人口人口.

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