在多囊性卵巢综合征中对淋巴细胞过的横截面研究
Alexandra E Butler1, Walaa Lubbad1, Shahzad Akbar2
1Research Department, Royal College of Surgeons in Ireland Bahrain, Busaiteen, Adliya P.O. Box 15503, Bahrain.
International journal of molecular sciences
|May 11, 2024
概括
淋巴细胞过 (GH) 与多囊性卵巢综合征 (PCOS) 有关,这表明功能可能下降. 研究表明,随着时间的推移,GH在PCOS患者中逐渐降低了EGFR,这表明炎症可能起作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 淋巴细胞过 (GH) 与多囊性卵巢综合征 (PCOS) 相关,并预测功能下降,代谢综合征和心血管疾病.
- 了解PCOS中GH与脏和全身健康之间的联系机制对于早期干预和管理至关重要.
研究的目的:
- 为了确定PCOS妇女中GH的患病率.
- 研究GH,炎症标记物,慢性病 (CKD) 标记物,管损伤标记物和PCOS中补充系统蛋白之间的关联.
- 评估二级队列中估计的膜过率 (eGFR) 的纵向变化.
主要方法:
- 对137名患有PCOS的女性和97名对照女性 (18-40岁) 的人口,代谢和蛋白质组数据进行了比较的横截面分析.
- SOMA扫描血蛋白质测量炎症蛋白,CKD标志物,管损伤标志物和补充蛋白.
- 二次队列研究分析了超过8.2-9.6年的eGFR变化.
主要成果:
- 44.5%的PCOS患者表现出GH (eGFR≥126mL/min/1.73m2),其中12%的患者表现出超级GH (SGH,eGFR≥142mL/min/1.73m2).
- 与PCOS-nonGH相比,PCOS-GH妇女的肌素和尿素水平较低.
- 在PCOS和对照群中观察到C反应蛋白 (CRP) 和白细胞计数 (WCC) 的升高. 与SGH相关的CRP.
- 观察到补充蛋白质的变化,PCOS-nonGH与PCOS-SGH的衰变加速因子 (DAF) 降低.
- 在PCOS-nonGH和PCOS-SGH中发现了降低的cystatin-c (CKD标志物).
- 在管损伤标志物中没有发现显著差异.
- 纵向分析显示,PCOS-nonGH,PCOS-GH和PCOS-SGH组在8.2-9.6年内逐渐降低了eGFR,SGH的下降幅度最高.
结论:
- GH与PCOS有关,并不是由管损伤介导的.
- 降低的cystatin-c和DAF,以及SGH中的CRP相关性,表明在更高的GH水平中炎症的潜在作用.
- 患有GH的PCOS患者的逐渐eGFR下降凸显了对CKD发展和管理的临床重要性.
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