相关实验视频
Updated: Jun 30, 2026

15:52
Postproduction Processing of Electrospun Fibres for Tissue Engineering
Published on: August 9, 2012
18.2K
用于组织工程应用的聚乙烯化物 (PVC) 纤维的增强电活性相
Angelika Zaszczyńska1, Arkadiusz Gradys1, Anna Ziemiecka2
1Laboratory of Polymers Biomaterials, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, Poland.
International journal of molecular sciences
|May 11, 2024
概括
这项研究优化了用于骨组织工程的聚乙烯化物 (PVDF) 纳米纤维支架. 较高的分子量PVDF和特定的电旋参数增强了压电特性和细胞兼容性,对骨再生应用有希望.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 聚合物科学 聚合物科学
背景情况:
- 纳米纤维材料对于组织再生,特别是骨重建至关重要.
- 开发具有与骨类似的压电性质的材料是骨组织工程的一个关键目标.
- 聚乙烯化物 (PVDF) 是一种具有骨架应用潜力的压电聚合物.
研究的目的:
- 为了研究PVDF分子量和电旋参数对脚手架属性的影响.
- 优化PVDF纳米纤维支架,用于增强压电和骨组织工程应用.
- 为了评估PVDF支架与人类脂肪衍生的树皮细胞的细胞相容性.
主要方法:
- 聚乙烯化物 (PVDF) 的电,具有不同的分子量 (180,000 g/mol和 530,000 g/mol).
- 电旋参数的系统变化:收集器旋转速度,应用电压和溶液流量.
- 福利埃变换红外光谱法 (FTIR) 用于分析电活性相含量.
- 使用人类脂肪基基基层细胞评估脚手架直径,压电系数和细胞相容性.
主要成果:
- 较高的PVDF分子量和增加的收集器旋转速度导致了更大的纳米纤维直径,更高的电活性相量含量和更好的压电系数.
- 电旋参数影响了电活性相含量,在22kV应用电压和0.8mL/h流量下获得最佳结果.
- PVDF支架表现出与人类脂肪衍生性树皮细胞的良好细胞兼容性,这表明骨质分化的潜力.
结论:
- 优化的PVDF纳米纤维支架表现出增强的压电特性,适合骨组织工程.
- 对于定制脚手架特性而言,PVDF分子量和电旋参数至关重要.
- 这些PVDF支架显示出作为骨再生生物材料的前景,需要进一步研究.
相关概念视频
Polymer Classification: Architecture
Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
Anionic Chain-Growth Polymerization: Overview
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
Types of Step-Growth Polymers: Polyesters
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Classification and Mechanical Properties of Synthetic Polymers
Synthetic polymers are classified as elastomers, fibers, or plastics based on their crystallinity. Crystallinity, the degree of long-range order in the solid state, influences the mechanical properties (stretching or contracting) of elastomers. Elastomers are flexible polymers that can expand or contract easily upon the application of an external force. They have numerous crosslinks that pull them back into their original shape when stress is removed. Silicones, for instance, are highly elastic...
Plasticizers
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Superplasticizers
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...

