在上胃肠道的小儿克朗氏病:临床,实验室,内镜和组织病理学分析
Dunja Putniković1, Jovan Jevtić1, Nina Ristić2
1Institute of Pathology "Prof. dr Đorđe Joannović", Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Diagnostics (Basel, Switzerland)
|May 11, 2024
概括
儿科克朗氏病 (CD) 患者在治疗后表现出症状减少和改善的实验室标记物,如便calprotectin和CRP. 定期评估对于监测疾病进展至关重要,特别是在下部肠道.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 克罗恩病 (CD) 是一种慢性,免疫媒介的胃肠道疾病.
- 儿科CD往往呈现出更广泛的疾病,包括上部消化道的参与.
- 组织病理学模式在儿科CD中有所不同,需要详细分析.
研究的目的:
- 分析儿科CD患者的临床,实验室,内镜和组织病理学发现.
- 为了比较克罗恩病儿童的初始和后续测试结果.
- 评估儿科CD的疾病进展和治疗有效性.
主要方法:
- 包括100名儿科CD患者接受内镜和组织病理 (HP) 程序.
- 在8年的时间里比较了多次活检的结果.
- 分析了临床症状,实验室值 (便calprotectin,CRP,albumin) 和内镜检查结果.
主要成果:
- 症状显著减少:便变化 (65.52%至18.18%),体重减轻 (35.24%至4%),腹部疼痛 (41.86%至6.67%).
- 改善的实验室值:便中的calprotectin (1000至60.8μg/g),CRP (12.2至1.9 mg/L),白蛋白 (36至41 g/L).
- 在32名患者中发现上部消化道的参与;在直肠和下垂结肠观察到疾病的进展,但不是上部消化道.
结论:
- 随访检查显示,儿科CD症状频率显著下降,实验室标记物改善.
- 定期的临床,实验室,内镜和组织病理学评估对于管理儿科CD至关重要.
- 超过三分之一的患者有特定的上部肠道内镜/HP发现,强调了全面评估的重要性.
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
219
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
219
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
113
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
113
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
166
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
166
01:17Chronic Bowel Disorders: Introduction
445
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
445
01:21Inflammatory Bowel Disease V: Surgical Management
145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
145