维生素D3缺乏,代谢综合征和VDR,GC和CYP2R1基因多态化之间的关系
Carmina Mariana Stroia1, Timea Claudia Ghitea2, Maria Vrânceanu3
1Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Nutrients
|May 11, 2024
概括
维生素D3缺乏与代谢综合征有关. 维生素D3代谢和运输的基因变异影响25(OH) D3水平,补充改善水平并帮助超重个体减肥.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 营养科学 营养科学
背景情况:
- 代谢综合征 (MS) 是一个日益严重的公共卫生问题.
- 在患有多发性硬化症的人群中,经常观察到维生素D3缺乏.
- 维生素D3代谢和运输途径的遗传变异可能会影响MS的发展和进展.
研究的目的:
- 研究维生素D3缺乏,MS和VDR,GC和CYP2R1基因中的多态性之间的关系.
- 评估维生素D3补充对生物化学参数和体重状况与这些基因多态相对应的影响.
主要方法:
- 一组58名参与者根据基因多态 (VDR,GC,CYP2R1) 和体重状况被分为四组.
- 生物化学参数包括25(OH) D3,脂质和HOMA指数在基线和12个月内被测量.
- 对具有多态基因的参与者进行了维生素D3补充.
主要成果:
- 所有接受维生素D3补充剂的具有多态基因的参与者都达到最佳的25(OH) D3水平.
- 在接受补充剂的超重患者 (POW组) 中观察到显著的体重减轻.
- 在VDR,GC和CYP2R1中的基因多态可能会影响维生素D3的状态和对补充剂的反应.
结论:
- 维生素D3补充剂在具有特定基因多态的个体中有效地使25 ((OH) D3水平正常化.
- 解决可能受遗传因素影响的维生素D3缺乏症可能是治疗代谢综合征和相关体重问题的治疗策略.
相关概念视频
01:23Role of Skin in Vitamin D Synthesis
5.2K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.2K
01:05Single Nucleotide Polymorphisms-SNPs
15.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.0K
02:19Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
01:19Overview of Carbohydrate Metabolism
944
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
944
02:26Comparing Copy Number Variations and SNPs
17.7K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.7K
01:28Human Genetics
561
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
561