在慢性压力成年人中Withania somnifera提取物的影响:随机对照试验
Srikanta Pandit1, Amit K Srivastav1, Tapas K Sur1
1Research Unit, Department of Health & Family Welfare, Government of Bengal, J. B. Roy State Ayurvedic Medical College and Hospital, 170-172, Raja Dinendra Street, Kolkata 700004, India.
Nutrients
|May 11, 2024
概括
阿什瓦甘达提取物可以安全地降低成年人的压力. 这项研究证实,每天125毫克的阿育吠陀草药对压力管理和HPA轴调节有效.
科学领域:
- 综合医学是一个整体的医学.
- 神经内分泌学神经内分泌学
- 植物化学 植物化学
背景情况:
- 慢性压力会对认知健康,福祉和生活质量产生负面影响.
- 长期的压力会破坏下丘脑-垂体-上腺 (HPA) 轴的平衡.
- 适应物,如Withhania somnifera (阿什瓦甘达),在阿育吠陀医学中用于减轻压力.
研究的目的:
- 支持根和叶子水中提取的阿什瓦甘达提取物 (WS) 在减轻压力的作用.
- 为了确认用于压力管理的最低临床验证剂量 (125 mg/天).
- 在自我报告高压力的成年人中进行剂量依赖的临床研究.
主要方法:
- 这是一项为期8周的随机,双盲,安慰剂控制的研究.
- 三种不同的WS提取物剂量的比较:125 mg,250 mg和500 mg.
- 在98名成年人中,使用感知压力量表 (PSS) 和生化参数测量压力减弱.
主要成果:
- 水性WS提取物 (根和叶) 可以安全地减少轻度至中度的慢性压力.
- 确定的有效剂量为125毫克,250毫克和500毫克/天,持续8周.
- 该研究证实了最低剂量 (125毫克/天) 的疗效.
结论:
- 水性WS提取物 (根和叶) 有效地减少了压力.
- 最低的有效剂量被证实为125毫克/天.
- 通过HPA轴调节,以剂量依赖的方式减少压力.
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