解读遗传风险得分与生活方式因素之间的相互作用,以及个人对肥胖的倾向
1Nutrition Department, Health Science Faculty, Ariel University, Ariel 40700, Israel.
Nutrients
|May 11, 2024
概括
遗传倾向和生活方式选择显著影响肥胖风险. 身体活动可以减轻遗传影响,突出针对肥胖管理的个性化策略.
科学领域:
- 遗传学和环境健康
- 肥胖问题研究研究
- 营养科学 营养科学
背景情况:
- 肥胖是一种复杂的疾病,受遗传倾向和环境因素的影响.
- 了解遗传风险和生活方式选择之间的相互作用对于有效的肥胖管理至关重要.
研究的目的:
- 调查BMI (GRSBMI) 的遗传风险得分与体力活动 (PA),含糖饮料 (SSB) 摄入量,葡萄酒消费和饮食习惯得分 (EHS) 对肥胖风险的综合影响.
- 确定遗传倾向如何与可修改的生活方式因素相互作用,从而预测肥胖.
主要方法:
- 分析了5824名成年人的数据,包括常见的与肥胖有关的单核酸多态和生活习惯.
- 构建一个加权的GRSBMI,分成四分位数.
- 使用调整的多变量逻辑回归模型来检查GRSBMI,肥胖和生活方式因素之间的联系.
主要成果:
- GRSBMI与肥胖风险的增加显著相关,每个单位的增加与3.06个BMI单位相关.
- 身体活动在所有GRSBMI四分位数中显著降低了肥胖风险.
- 不健康的饮食习惯,高SSB消费和非葡萄酒饮酒与更高的BMI有关,特别是在具有更高遗传风险的个体中.
结论:
- 较高的BMI遗传风险得分可以放大有害的生活方式因素对肥胖的影响.
- 通过考虑遗传风险和可修改的生活方式选择之间的相互作用,可以制定个性化的肥胖预防和治疗策略.
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