血液中的水平是男性癌症风险的标志物
Róża Derkacz1, Wojciech Marciniak1, Piotr Baszuk2
1Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Dobra, Poland.
Nutrients
|May 11, 2024
概括
男性的高 (Cd) 含量显著增加癌症风险,特别是在非吸烟者和年轻人中. 尽量减少暴露对于预防癌症至关重要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 癌症流行病学 癌症流行病学
背景情况:
- (Cd) 是一种已知的致癌物.
- 低度对癌症风险的影响尚不清楚.
- 之前关于Cd和男性癌症风险的研究产生了不一致的结果.
研究的目的:
- 研究血液中含量与男性癌症发病率之间的关联.
- 为了探索年龄和吸烟状态的潜在修饰效应.
主要方法:
- 对2956名男性进行了前性队列研究.
- 测量了血液中的含量.
- 参与者被跟踪78个月,以追踪癌症发病率.
主要成果:
- 血中含量高 (>0.71μg/L) 的男性患癌症的风险增加了3.42倍 (p < 0.001).
- 这种风险在非吸烟者 (HR 3.74,p = 0.003) 和不同年龄组 (<60:HR 2.79,p = 0.017;≥60:HR 4.63,p = 0.004) 中较高.
- 在这个队列中,吸烟并没有显著改变Cd-癌症风险关系.
结论:
- 血中含量升高与男性癌症风险增加有关.
- 减少暴露对于癌症预防策略至关重要.
- 需要对不同种群进行进一步的研究来证实这些发现.
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