甘油三和高密度胆固醇的比例用于确定肥胖中MASLD:基于肝脏活检的病例对照研究
José Ignacio Martínez-Montoro1, María Antonia Martínez-Sánchez2, Andrés Balaguer-Román2,3
1Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Faculty of Medicine, University of Malaga, 29010 Malaga, Spain.
Nutrients
|May 11, 2024
概括
甘油三和高密度脂蛋白胆固醇 (TG/HDL-C) 的比率可能表明肥胖患者的代谢功能障碍相关的脂肪性肝病 (MASLD). 然而,与本研究中的单个脂质水平相比,这种比率并没有改善MASLD检测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 失脂症经常与代谢功能障碍相关的脂肪性肝病 (MASLD) 相关.
- 甘油三与高密度脂蛋白胆固醇 (TG/HDL-C) 的比率已被提议作为MASLD的非侵入性标志物,特别是通过超声波评估时.
- 对于活检证明的MASLD及其特定阶段的TG/HDL-C比率的诊断实用性仍未得到充分研究.
研究的目的:
- 调查TG/HDL-C比率在肥胖患者中鉴定活检证明的MASLD时的有效性.
- 为了比较TG/HDL-C比率与个体甘油三 (TG) 和高密度脂蛋白胆固醇 (HDL-C) 水平的诊断性能.
主要方法:
- 一项涉及153名肥胖患者的病例控制研究,这些患者接受了肝脏活检的代谢手术.
- 患者被分为没有MASLD,代谢功能障碍相关的脂肪性肝 (MASL) 和代谢功能障碍相关的脂肪性肝炎 (MASH) 组.
- 采用接收器操作特征 (ROC) 分析来评估TG/HDL-C比率的诊断准确性,并比较曲线下的面积 (AUC).
主要成果:
- 患有MASLD的患者与没有MASLD的患者相比,TG/HDL-C比率显著更高.
- 在MASL和MASH组之间没有观察到TG/HDL-C比率的显著差异.
- TG/HDL-C比率显示了检测MASLD的最高AUC (0.747),截止值为3.7 (灵敏度为70%,特异性为74.5%).
- 然而,TG/HDL-C比率的AUC在统计学上并不优于MASLD检测的单个TG或HDL-C水平.
结论:
- 在肥胖患者中,高TG/HDL-C比率与活检证明的MASLD有关.
- 尽管存在关联,但TG/HDL-C比率并没有改善MASLD的诊断性能,而不是仅仅与血清TG或HDL-C相比.
- 可能需要进一步的研究来完善脂质比在MASLD诊断中的实用性.
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