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Published on: January 27, 2019
碳水化合物介导的怀孕肠道微生物群和新生儿低出生体重
Hong-Ren Yu1, Yao-Tsung Yeh2, Hong-Tai Tzeng3
1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
孕妇在怀孕期间摄入的碳水化合物与婴儿出生体重低 (LBW) 有关. 肠道细菌发挥着作用,某些物种影响胎儿生长和出生体重,为预防提供了潜在的目标.
科学领域:
- 产科和妇科 产科和妇科
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 低出生体重 (LBW) 是一个重要的全球健康问题.
- 母亲的饮食,特别是碳水化合物摄入量,以及肠道微生物群的组成都与胎儿发育和出生结果有关.
- 母亲饮食,肠道微生物群和LBW之间的相互作用需要进一步阐明.
研究的目的:
- 研究肠道微生物群对母亲碳水化合物摄入量与新生儿低出生体重 (LBW) 之间的关联的影响.
- 确定与胎儿生长和出生体重相关的特定肠道微生物物种.
- 探索孕产妇高血压在改变这些关系中的作用.
主要方法:
- 一项前性队列研究,涉及台湾的257对母婴.
- 通过问卷评估母亲的饮食摄入量,将宏观营养素分为低,中或高.
- 使用16S rRNA基因测序分析肠道微生物群组成和多样性的孕产妇便样本.
主要成果:
- 母亲的碳水化合物摄入量与婴儿的LBW正相关.
- 包括Bacteroides ovatus,Dorea spp.和Rosenburia faecis在内的特定细菌显示出与胎儿生长和出生体重的显著关联.
- 孕产妇高血压改变了微生物群的特征,并与胎儿生长不佳有关.
结论:
- 肠道微生物群的组成调节了母亲的碳水化合物摄入量和新生儿的LBW之间的关系.
- 微生物群可访问的碳水化合物可能会影响怀孕的肠道微生物群,为预防LBW提供了潜在的策略.
- 针对肠道微生物群的干预措施可能对高血压和LBW风险的孕妇有益.
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