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个性化饮食对养状况和功能结果在切除癌患者个性化饮食的影响
Francesco Trevisani1,2, Fabiana Laurenti3, Francesco Fiorio1
1Division of Experimental Oncology, Urological Research Institute, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Nutrients
|May 11, 2024
概括
低正常蛋白,高热量 (LNPHC) 饮食改善了细胞癌 (RCC) 患者的营养状况. 这种地中海风格的饮食有助于预防营养不良,并保持这些瘤神经病患者的体细胞质量.
科学领域:
- 瘤学和脏学
- 临床营养学 临床营养学
- 细胞癌 (RCC) 管理管理
背景情况:
- 慢性病 (CKD) 管理通常涉及受控的蛋白质摄入 (营养疗法,NT).
- 癌症患者经常接受高蛋白饮食以防止营养不良,为瘤神经病患者造成冲突.
- 针对瘤脏病患者的指导方针,特别是那些在RCC后患有孤独脏患者,缺乏明确的营养策略.
研究的目的:
- 为了研究低正常蛋白,高卡路里 (LNPHC) 地中海饮食在切切除RCC患者的疗效.
- 评估饮食对营养参数的影响,并预防这种特定患者队列中的营养不良.
主要方法:
- 招募了40名成年腎切除RCC患者的群組,這些患者接受了營養不良查 (營養不良查工具 [MST] <2).
- 患者接受了为期6个月 (±2个月) 的常规CKD LNPHC饮食 (0.8g/kg/day蛋白质,30-35kcal/kg/day).
- 评估的参数包括MST,BMI,相角,身体组成 (BCMI,FFMI),水平衡 (ECW/ICW) 和尿素水平.
主要成果:
- LNPHC饮食显著改善了营养参数,防止了营养不良和代谢.
- 关键的改进包括保存的体细胞质量指数 (BCMI),减少细胞外矩阵/体细胞质量 (ECM/BCM) 比率,以及减少细胞外水/细胞内水 (ECW/ICW) 比率.
- 这种饮食还增加了总体水分 (TBW),保持了无脂肪质量 (FFM),减少了脂肪质量 (FM),并显著降低了尿素水平.
结论:
- 低正常蛋白,高热量 (LNPHC) 饮食是一种有效的治疗策略,用于因癌而患有孤独脏的瘤脏病患者.
- 这种饮食方法成功地解决了这种脆弱人群中CKD和癌症的双重挑战.
- 这些发现支持将LNPHC饮食纳入临床实践,用于治疗切除RCC患者.
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