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双重药物载荷的智能细胞系统的体和生物特征

Hildegard Herman¹, Delia M Rata², Anca N Cadinoiu²

¹"Aurel Ardelean" Institute of Life Sciences, Vasile Goldis Western University, Rebreanu Street, No. 86, 310414 Arad, Romania.

|May 11, 2024

概括

智能聚合物微粒 (PMs) 有效地输送了帕克利塔塞尔 (PTX) 和乌尔索酸 (UA),显示出增强的抗癌作用. 双重载荷的PMs表现出协同作用,改善瘤细胞抑制.

科学领域:

聚合物科学聚合物科学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

智能聚合物微粒 (PMs) 对于药物输送至关重要,因为它们的小尺寸和低临界微粒度.
聚2-乙烯) -b-聚乙烯氧化物) (P2VP-b-PEO) 共聚合物是适用于药物封装的pH敏感材料.

研究的目的:

为了研究包装帕克利塔塞尔 (PTX) 和乌尔索酸 (UA) 进入P2VP-b-PEO聚合物微粒.
为了评估药物载体PMs对4T1乳腺癌小鼠细胞的体外疗效.

主要方法:

使用两种不同的P2VP-b-PEO共聚合物样本通过透析制备聚合物微粒.
将PTX,UA或两种药物加载到准备好的粒中.
使用FT-IR光谱学进行细胞大小,药物加载效率和相互作用的表征.
在实验室中对4T1细胞进行的细胞毒性研究,这些细胞接受了药物载荷的PMs的治疗.

主要成果:

形成了大约35nm和140nm的球形颗粒物,在药物加载后尺寸增加.
药物封装效率在53%至94%之间,加载效率在3.2%至18.7%之间.
带有PTX和PTX/UA的PM显著抑制了瘤细胞活力,在双重负载中观察到协同效应.
装有酸的PM和空的PM的疗效有限.

结论:

P2VP-b-PEO共聚合物是PTX和UA的有效载体,形成稳定的聚合物微粒.
在PM中对PTX和UA的双重负载显示出对4T1细胞的协同抗癌效应.
这些智能聚合物微粒显示出增强癌症治疗的前景.

关键词:

药物输送系统是药物输送系统.对于pH值敏感的聚合物微粒帕克利塔克塞尔 (paclitaxel) 是一种药物.聚2-乙烯胺) -b-聚乙烯氧化物)乌尔索酸是什么意思乌尔索酸是什么意思

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