便挥发性有机化合物分析在De Novo儿科炎性肠病的气体染色学-离子移动谱学:一个案例对照研究
Eva Vermeer1,2,3, Jasmijn Z Jagt1,2,3, Trenton K Stewart4
1Department of Paediatric Gastroenterology, Emma Children's Hospital, Amsterdam University Medical Centre, 1105 AZ Amsterdam, The Netherlands.
Sensors (Basel, Switzerland)
|May 11, 2024
概括
便挥发性有机化合物 (VOC) 概况区分儿科炎症性肠病 (IBD) 患者与对照者. 然而,基线VOC模式无法预测这些年轻IBD患者的治疗反应.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群和代谢物在炎症性肠病 (IBD) 中有所不同.
- 挥发性有机化合物 (VOC) 是具有诊断潜力的微生物代谢物.
- 关于VOC概况和治疗反应的儿科IBD患者数据有限.
研究的目的:
- 为了比较儿科IBD患者和有胃肠道症状 (CGI) 的对照组之间的便VOC概况.
- 为了确定基线VOC概况是否可以预测儿科IBD患者的治疗反应.
主要方法:
- 从未接受过治疗的儿科IBD患者和CGI (4-17岁) 收集了便样本.
- 气色谱-离子移动性光谱法 (GC-IMS) 用于VOC分析.
- 治疗反应是由临床评分定义的,没有治疗升级.
主要成果:
- 与CGI相比,儿科IBD患者表现出明显的便VOC概况 (AUC0.71,p<0.001).
- 在克罗恩病 (AUC 0.75) 和性结肠炎 (AUC 0.67) 患者中观察到明显的VOC概况.
- 在响应者和不响应者之间没有发现基线VOC概况的显著差异 (AUC 0.70,p=0.1).
结论:
- 便的VOC档案显著区分儿科IBD患者与CGI.
- 目前的VOC分析不能预测儿科IBD患者的治疗反应.
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