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微RNAs (miRNAs) 在良性泌尿病中的表达:系统性审查
Morteza Atayi1, Nasim Mahdavi2, Hanieh Salehi-Pourmehr3
11. Research Center for Evidence-Based Medicine, Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. m.atayi6722@gmail.com.
Urology journal
|May 11, 2024
概括
本综述强调了特定的microRNAs (miRNAs) 作为早期检测和治疗良性泌尿病的潜在生物标志物,例如过度活跃的膀和膀出口阻塞.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 良性泌尿病的分子机制尚不清楚.
- 微RNAs (miRNAs) 涉及过度活性膀 (OAB),膀出口阻塞 (BOO) 和膀疼痛综合征/间歇性囊炎 (BPS/IC) 等疾病的病理生理学.
结论:
- 特定的miRNAs,包括92a-3p,miR-21,miR-199a-5p,miR-146a-5p和491-5p,显示出作为良性泌尿病的生物标志物和治疗点的潜力.
- 技术进步可能使基于RNA的疗法能够开发,以确保安全的患者治疗.
相关概念视频
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...